… Hence, MHC I deficiency or CD8 T cell blockade protects … these regulatory CD8 T cells is
lower during MS exacerbations … with irradiated neuroantigen-specific CD4 T cell clones, lyse …

… class I and that neuroantigen-specific CD8 + T cells infiltrate … The concept of anti-neuronal
CD8 + T cell–initiated gray matter … the pathogenic role of neuronal antigen–specific CD8 + T …

… Indeed, adoptive transfer of neuroantigen-specific CD8 + T … of CD8 + Tregs could
restore/improve a deficient immune … factor is critical for regulatory T cell activation and stability. …

… and whether they contribute to the worsening of the condition. It is envisaged that the … immune
adaptive response to optimize regulatory T cell functions [33]. Multiple studies also point to …

… the regulatory role of CD8 + T cells in MS. Although the impairment of CD8 + T-cell tolerance
is thought to play a crucial role in … Furthermore, PD-1– and PD-L1–deficient mice are more …

… This argument was based on the realization that 12p40-defective mice did not develop MS
symptoms. … molecules interact to influence T cell function. Effector T cells in multiple sclerosis …

… -naive MS during exacerbations and progression, but CD8 + … 45% of CD8 + cells, increasing
the CD8/CD4 T-cell ratio in blood… basis, and defective CD8 Treg function is more subnormal …

… ), express reduced levels of FOXP3 and have defective suppressive activity in vitro (28). This
… and mimic T-cell help for further differentiation in GCs (5, 22, 56, 57). During acute infection, …

… induce a hyperreactive but defective CD8 T-cell response, as … susceptibility variants regulate
T cell differentiation and function (6… Despite MAIT-like cells could play a role in exacerbating …

… -specific CD8 + T cells recruited to the CNS during CD4 + T cell–… Multiple sclerosis (MS) is
an autoimmune disease of the … induced in Fas-deficient mice was indistinguishable from the …